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Hideyuki Okano Selected Research

Biomarkers (Surrogate Marker)

1/2023Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
1/2020Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages.
7/2018HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer.
11/2016Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience.
5/2016Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
7/2015Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses.

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Hideyuki Okano Research Topics

Disease

84Spinal Cord Injuries (Spinal Cord Injury)
04/2024 - 03/2004
40Neoplasms (Cancer)
04/2023 - 10/2004
20Neurodegenerative Diseases (Neurodegenerative Disease)
04/2024 - 06/2002
20Parkinson Disease (Parkinson's Disease)
10/2023 - 10/2002
17Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
12/2023 - 01/2006
16Inflammation (Inflammations)
01/2024 - 05/2003
14Ischemia
10/2018 - 03/2002
13Alzheimer Disease (Alzheimer's Disease)
04/2024 - 10/2006
13Brain Ischemia (Cerebral Ischemia)
10/2013 - 05/2003
11Hearing Loss (Hearing Impairment)
01/2023 - 04/2010
10Stroke (Strokes)
10/2018 - 10/2004
8Gliosis
03/2024 - 06/2005
8Glioma (Gliomas)
04/2023 - 04/2005
7Infarction (Infarctions)
04/2024 - 06/2005
7Schizophrenia (Dementia Praecox)
10/2023 - 01/2014
7Sarcoma (Soft Tissue Sarcoma)
04/2023 - 07/2013
7Carcinogenesis
01/2023 - 04/2002
7Glioblastoma (Glioblastoma Multiforme)
01/2020 - 05/2011
7Hypertension (High Blood Pressure)
01/2019 - 04/2005
7Hypoxia (Hypoxemia)
01/2017 - 05/2010
6Teratoma (Teratoid Tumor)
01/2013 - 10/2009
5Cicatrix (Scar)
01/2024 - 12/2005
5Wounds and Injuries (Trauma)
09/2023 - 03/2005
5Brain Neoplasms (Brain Tumor)
09/2022 - 04/2005
5Mitochondrial Diseases (Mitochondrial Disease)
01/2021 - 10/2012
5Neurodevelopmental Disorders
01/2020 - 05/2015
5Demyelinating Diseases (Demyelinating Disease)
10/2018 - 08/2003
4Epilepsy (Aura)
01/2021 - 01/2010
4Autistic Disorder (Autism)
01/2020 - 07/2015
4Hyperalgesia
11/2018 - 01/2011
4Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
10/2018 - 06/2005
4Central Nervous System Diseases (CNS Diseases)
09/2016 - 01/2008
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013 - 11/2006
4Nervous System Diseases (Neurological Disorders)
09/2012 - 02/2009
3Peripheral Nerve Injuries
02/2024 - 10/2012
3Motor Neuron Disease (Primary Lateral Sclerosis)
04/2023 - 03/2013
3Astrocytoma (Pilocytic Astrocytoma)
04/2023 - 05/2011
3Brain Injuries (Brain Injury)
01/2023 - 06/2005
3CHARGE Syndrome
12/2022 - 11/2017
3Dementia (Dementias)
12/2022 - 01/2020
3Liposarcoma
01/2022 - 07/2013
3Atrophy
11/2021 - 03/2013
3Sensorineural Hearing Loss
01/2021 - 01/2012
3Cerebral Infarction
01/2020 - 02/2006
3Breast Neoplasms (Breast Cancer)
07/2018 - 08/2010
3Brain Diseases (Brain Disorder)
01/2018 - 07/2015
3Melanoma (Melanoma, Malignant)
10/2017 - 01/2013
3Neoplasm Metastasis (Metastasis)
01/2017 - 06/2012
3Fibrosis (Cirrhosis)
01/2016 - 10/2007
3Neuralgia (Stump Neuralgia)
09/2015 - 03/2013

Drug/Important Bio-Agent (IBA)

37Proteins (Proteins, Gene)FDA Link
12/2023 - 04/2002
18RNA-Binding Proteins (RNA-Binding Protein)IBA
11/2022 - 04/2002
12CytokinesIBA
04/2024 - 08/2003
11NestinIBA
01/2024 - 09/2002
10Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
03/2024 - 08/2007
9Interleukin-6 (Interleukin 6)IBA
01/2014 - 06/2005
7Retinaldehyde (Retinal)IBA
10/2023 - 12/2006
7Messenger RNA (mRNA)IBA
11/2022 - 04/2002
7salicylhydroxamic acid (SHAM)IBA
01/2018 - 03/2002
6Therapeutic UsesIBA
04/2024 - 12/2006
6RNA (Ribonucleic Acid)IBA
04/2024 - 05/2016
6Biomarkers (Surrogate Marker)IBA
01/2023 - 07/2015
6DNA (Deoxyribonucleic Acid)IBA
01/2022 - 09/2005
6SynucleinsIBA
01/2021 - 01/2012
6Bromodeoxyuridine (BrdU)IBA
11/2005 - 03/2002
5Apolipoproteins E (ApoE)IBA
04/2024 - 12/2017
5Semaphorin-3AIBA
01/2024 - 12/2006
5Transcription Factors (Transcription Factor)IBA
01/2017 - 09/2005
4ropinirole (Requip)FDA LinkGeneric
12/2023 - 09/2019
4gamma-Aminobutyric Acid (GABA)IBA
10/2023 - 01/2010
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2023 - 06/2007
4ChromatinIBA
12/2022 - 06/2008
4Protein Isoforms (Isoforms)IBA
11/2022 - 10/2003
4Phosphotransferases (Kinase)IBA
12/2020 - 03/2013
4Indicators and Reagents (Reagents)IBA
05/2020 - 06/2003
4Galectin 1 (LGALS1)IBA
07/2012 - 10/2007
4Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
08/2010 - 06/2005
4Granulocyte Colony-Stimulating Factor (G-CSF)IBA
11/2007 - 12/2004
4InterleukinsIBA
06/2007 - 06/2005
3Serine (L-Serine)FDA Link
04/2023 - 05/2011
3SteroidsIBA
01/2023 - 01/2012
3Amyloid (Amyloid Fibrils)IBA
01/2022 - 01/2020
3polyglutamineIBA
06/2021 - 03/2013
3MicroRNAs (MicroRNA)IBA
01/2021 - 01/2012
3Androgen Receptors (Androgen Receptor)IBA
01/2020 - 03/2013
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
12/2018 - 01/2013
3Glial Fibrillary Acidic ProteinIBA
10/2018 - 04/2010
3Oxygen (Dioxygen)IBA
10/2018 - 03/2012
3UbiquitinIBA
01/2017 - 09/2008
3Chondroitin ABC LyaseIBA
12/2016 - 12/2005
3STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
09/2015 - 07/2005
3Small Interfering RNA (siRNA)IBA
06/2012 - 05/2011

Therapy/Procedure

71Therapeutics
04/2024 - 10/2002
62Transplantation
04/2024 - 10/2002
11Cell Transplantation
04/2024 - 01/2007
9Cell- and Tissue-Based Therapy (Cell Therapy)
01/2024 - 04/2008
6Stem Cell Transplantation
01/2023 - 01/2006
4Drug Therapy (Chemotherapy)
01/2021 - 05/2008
3Catheters
07/2014 - 11/2005
3Injections
01/2012 - 01/2007